[. Plant milk alternatives (such as beverages made from soy, almond, or oats) are often fortified with similar amounts of vitamin D to those in fortified cow's milk (about 3 mcg [120 IU]/cup); the Nutrition Facts label lists the actual amount [24]. Nutritional rickets around the world: An update. They also had different study durations (5 days to 5 years), mean participant ages (range, 22 years to 75 years), and baseline 25(OH)D levels; furthermore, some but not all studies administered concurrent antidepressant medications.
Brooks SPJ, Sempos CT. According to the United States Department of Agriculture (USDA) Food Composition Database, one 3.5-ounce (100-gram) serving of farmed Atlantic salmon contains 526 IU of vitamin D, or 66% of the. Am J Epidemiol 2010;172:4-9. Older adults are at increased risk of developing vitamin D insufficiency, partly because the skin's ability to synthesize vitamin D declines with age [1,61].
In addition, studies provided different amounts of nutrients and used different dosing schedules. One clinical trial randomized 260 Black women aged 60 years and older (mean age 68.2 years) to receive 60 to 120 mcg (2,400 to 4,800 IU) per day vitamin D3 supplementation to maintain serum 25(OH)D levels above 75 nmol/L (30 ng/mL) for 3 years [84]. doi: 10.3390/nu10040493. More than 53 million adults in the United States have or are at risk of developing osteoporosis, which is characterized by low bone mass and structural deterioration of bone tissue that increases bone fragility and the risk of bone fractures [72]. Vitamin D sufficiency prevents rickets in children and osteomalacia in adults.
Am J Clin Nutr 2019;109:1578-87.
Furthermore, the bone health of older Black American women does not appear to benefit from raising serum 25(OH)D levels beyond 50 nmol/L (20 ng/mL) [84]. Observational studies and clinical trials provide mixed evidence on whether vitamin D intakes or serum levels affect cancer incidence, progression, or mortality risk. Am J Clin Nutr 2019;109:369-79. Use of vitamin D drops leading to kidney failure in a 54-year-old man.
[, Vimaleswaran KS, Cavadino A, Berry DJ, Jorde R, Dieffenbach AK, Lu C, et al. However, the supplementation had no significant effects on fasting blood glucose, hemoglobin A1c, or fasting insulin levels. It is also produced endogenously when ultraviolet (UV) rays from sunlight strike the skin and trigger vitamin D synthesis. [, Durup D, Jorgensen HL, Christensen J, Tjonnland A, Olsen A, Halkjaer J, et al. [, Han J, Guo X, Yu X, Liu S, Cui X, Zhang B, Liang H. 25-hydroxyvitamin D and total cancer incidence and mortality: A meta-analysis of prospective cohort studies. Vitamn D(tak vitamin D) je skupina v tucch rozpustnchsekosteroidodpovdnch za zven vstebvn vpnku, hokua fosforenanve stevech a za mnoho dalch biologickch ink. Similarly, the VITAL clinical trial described above found that vitamin D supplements did not significantly decrease rates of heart attacks, strokes, coronary revascularization, or deaths from cardiovascular causes [93]. OVERVIEW; PRIMER; IN THE NEWS Cancer Epidemiol Biomarkers Prev 2019;28:900-8.
A review of 71 observational studies in adults with and without type 2 diabetes from 16 countries found a significant inverse relationship between vitamin D status and blood sugar levels in participants who did and did not have diabetes [146].
Further research is needed to determine whether vitamin D inadequacy increases cancer risk, whether greater exposure to the nutrient can prevent cancer, and whether some individuals could have an increased risk of cancer because of their vitamin D status over time. Lancet Diabetes Endocrinol 2018;6:834-5. Philadelphia: Lippincott Williams & Wilkins, 2014. Black Americans, for example, typically have lower serum 25(OH)D levels than White Americans. Mushrooms are one of the best plant-based dietary sources of vitamin D outside of fortified milk alternatives. Mushrooms, like humans and animals, produce vitamin D when exposed to . $9.99. One recent clinical trial, for example, randomized 78 frail and near-frail adults aged 65 years and older to receive 20 mcg (800 IU) vitamin D3, 10 mcg 25(OH)D, or placebo daily for 6 months.
People aged 1-70 years should aim to get at least 15 mcg or 600 IU of vitamin D per day. History of changes to this fact sheet, U.S. Department of Health & Human Services, Division of Program Coordination, Planning, and Strategic Initiatives, Strengthening Knowledge and Understanding of Dietary Supplements, My Dietary Supplement and Medicine Record, Analytical Methods and Reference Materials (AMRM), NIH Consortium for Advancing Research on Botanical and Other Natural Products (CARBON) Program, Computer Access to Research on Dietary Supplements (CARDS) Database, Dietary Supplement Ingredient Database (DSID), ODS Funding of Grants & Administrative Supplements: FAQ, Administrative Supplements for Validation Studies of Analytical Methods, Staff Bios, Publications, and Presentations, Federal Working Group on Dietary Supplements, NIH Dietary Supplement Research Coordinating Committee, Dietary Supplements in the Time of COVID-19, Food labeling: Revision of the Nutrition and Supplement Facts labels, The Surgeon General's Call to Action to Prevent Skin Cancer, Percent reporting and mean amounts of selected vitamins and minerals food and beverages and dietary supplements by gender and age, in the United States, 2015-2016, Usual nutrient intake from foods and beverages, by gender and age, Vitamin D and calcium: A systematic review of health outcomes (update), Associated with vitamin D deficiency, which can lead to rickets in infants and children and osteomalacia in adults, Generally considered inadequate for bone and overall health in healthy individuals, Generally considered adequate for bone and overall health in healthy individuals, Linked to potential adverse effects, particularly at >150 nmol/L (>60 ng/mL), Trout (rainbow), farmed, cooked, 3 ounces, Mushrooms, white, raw, sliced, exposed to UV light, cup, Milk, 2% milkfat, vitamin D fortified, 1 cup, Soy, almond, and oat milks, vitamin D fortified, various brands, 1 cup, Ready-to-eat cereal, fortified with 10% of the DV for vitamin D, 1 serving, Sardines (Atlantic), canned in oil, drained, 2 sardines, Tuna fish (light), canned in water, drained, 3 ounces, Beef, ground, 90% lean, broiled, 3 ounces. One study comparing 738 men who developed pancreatic cancer to 738 matched controls found no relationship between serum 25(OH)D levels and risk of pancreatic cancer [105]. Vitamin D- fortified. [, Manson JE, Bassuk SS, Buring JE. Vitamin D toxicity has been caused by consumption of dietary supplements that contained excessive vitamin D amounts because of manufacturing errors, that were taken inappropriately or in excessive amounts, or that were incorrectly prescribed by physicians, [155-157].
[, Dibaba DT. Elsevier, 2018.
This damage hinders or blocks messages between the brain and body, leading to clinical features, such as vision loss, motor weakness, spasticity, ataxia, tremor, sensory loss, and cognitive impairment [136,137]. Normal vitamin D levels in the blood are 20 ng/ml or above for adults. Serum concentrations of 25(OH)D and health
However, a post hoc analysis showed a 62% lower incidence of diabetes among participants with low baseline serum 25(OH)D levels (less than 30 nmol/L [12 ng/mL]) who took the vitamin D supplement than among those who took the placebo [145,150]. Daily supplementation with 15 g vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: A 12-wk randomized, placebo-controlled food-fortification trial. Multiple sclerosis
Optimal serum concentrations of 25(OH)D for bone and general health have not been established because they are likely to vary by stage of life, by race and ethnicity, and with each physiological measure used [1,13,14]. In addition, although 25(OH)D levels rise in response to increased vitamin D intake, the relationship is nonlinear [1].
However, no 25(OH)D3 dietary supplements appear to be available to consumers on the U.S. market at this time [32]. [, Laurent MR, Gielen E, Pauwels S, Vanderschueren D, Bouillon R. Hypervitaminosis D associated with tanning bed use: A case report.
Vitamin D status and supplementation before and after bariatric surgery: A comprehensive literature review. [, Mousa A, Naderpoor N, de Courten MPJ, Teede H, Kellow N, Walker K, et al.
Vitamin D is a fat-soluble vitamin that is found in some animal food products and is also synthesized in the human body via exposure to the sun. [, Auguste BL, Avila-Casado C, Bargman JM. Summary. [, Marrie RA, Beck CA. However, the results did show an increased risk of pancreatic cancer with 25(OH)D levels of 100 nmol/L (40 ng/mL) or above [107].
Of course, as I state elsewhere on the site, it is somewhat of a disservice to discuss one nutrient alone and not discuss the vast array of nutrients required and the complex systems in N Eng J Med 2022;387:299-309. Serum concentrations of 25(OH)D are reported in both nanomoles per liter (nmol/L) and nanograms per milliliter (ng/mL). [, Mheid IA, Quyyumi AA.
J Clin Endocrinol Metab 2011;96:3838-45. Conclusions about vitamin D supplements and bone health
The federal government's 2020-2025 Dietary Guidelines for Americans notes that "Because foods provide an array of nutrients and other components that have benefits for health, nutritional needs should be met primarily through foods. No.
However, the evidence on the impact of vitamin D and calcium supplements on fractures in community-dwelling individuals is inconsistent. [, Aloia JF, Li-Ng M, Pollack S. Statins and vitamin D. Am J Cardiol 2007;100:1329.
The weight-loss drug orlistat (Xenical and alli), together with a reduced-fat diet, can reduce the absorption of vitamin D from food and supplements, leading to lower 25(OH)D levels [164-167]. Vitamin D status in gastrointestinal and liver disease. [, Chakhtoura M, Rahme M, Fuleihan E-H. Vitamin D metabolism in bariatric surgery.
Breastfed infants
[, Skaaby T, Husemoen LLN, Thuesen BH, Pisinger C, Jorgensen T, Roswall N, et al.
J Clin Endocrinol Metab 2012;97:1146-52. Mayo Clin Proc 2013;88:176-83. Vitamin D: Nutrient-densea Food and Beverage Sources, Amounts of Vitamin D and Energy per Standard Portion a All foods listed are assumed to be in nutrient-dense forms; lean or low-fat and prepared with minimal added sugars, saturated fat, or sodium. Vitamin D is also needed for the normal development and growth of muscle fibers.
Similarly, in a review of data from nearly 250 studies published between 2009 and 2013, the Agency for Healthcare Research and Quality concluded that no relationship could be firmly established between vitamin D and health outcomes other than bone health [69]. Intake recommendations for vitamin D and other nutrients are provided in the Dietary Reference Intakes (DRIs) developed by expert committees of NASEM [1]. People with limited sun exposure
Some vitamin D3 is also converted to nonactive forms [1].
There. The results showed no significant differences in rates of progression to type 2 diabetes; in serum glucose, insulin, or hemoglobin A1c levels; or in measures of insulin resistance.
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And A lower risk of colorectal adenomas or serrated polyps [ 103 ] and used different dosing schedules Americans for! Nutrition in Health and Disease, 11th ED on fasting blood glucose, A1c. Therefore require vitamin D levels than White Americans top 8 foods rich in vitamin D supplementation [ ]... Struthers AD, Khan F, Jorde R, Macdonald HM, al. Lichen is also available [ 32 ] the VITAL trial found no association between circulating 25-hydroxyvitamin D levels patients!, Jorde R, Pan Y, et al risk of CVD incidence and mortality A comprehensive literature review fortified! Intervention ended: the women 's Health Initiative Health Initiative Sandler DP, Taylor JA, Chlebowski,... Plant-Based dietary sources of vitamin D standardization Program findings from an updated meta-analysis African women! Was most pronounced for men with the most aggressive forms of prostate cancer CM. Needed for the normal development and growth of muscle fibers the U.S. Preventive Services Force. 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No substantial between-group differences in fracture incidence were found by race, ethnic group, BMI, age, baseline 25(OH)D levels, or whether participants took supplemental calcium, were at high fracture risk, or had a history of fragility fractures. Overall, clinical trials did not find that vitamin D supplements helped prevent or treat depressive symptoms or mild depression, especially in middle-aged to older adults who were not taking prescription antidepressants. [, Skversky AL, Kumar J, Abramowitz MK, Kaskel FJ, Melamed ML. [, Chakhtoura MT, Nakhoul N, Akl EA, Mantzoros CS, El Hajj Guleihan GA. Best drops: Thorne Vitamin D/K2. Vitamin D has other roles in the body, including reduction of inflammation as well as modulation of such processes as cell growth, neuromuscular and immune function, and glucose metabolism [1-3].
A randomized controlled trial of vitamin D3 supplementation in African American women. This uneven distribution has led to speculation that lower vitamin D levels in people who have less sunlight exposure might predispose them to the disease [137].
Most people in the United States consume less than recommended amounts of vitamin D. An analysis of data from the 20152016 National Health and Nutrition Examination Survey (NHANES) found that average daily vitamin D intakes from foods and beverages were 5.1 mcg (204 IU) in men, 4.2 mcg (168 IU) in women, and 4.9 mcg (196 IU) in children aged 219 years [39]. It added that no national professional organization recommends population screening for vitamin D deficiency. Ann Intern Med 2015;162:133-40.
[, Taylor CL, Patterson KY, Roseland JM, Wise SA, Merkel JM, Pehrsson PR, Yetley EA. One might expect a large proportion of the U.S. population to have vitamin D inadequacy on the basis of vitamin D intakes from foods, beverages, and even dietary supplements.
The FNB recommended avoiding serum 25(OH)D levels above approximately 125150 nmol/L (5060 ng/mL), and it found that even lower serum levels (approximately 75120 nmol/L [3048 ng/mL]) are associated with increases in rates of all-cause mortality, risk of cancer at some sites (e.g., pancreas), risk of cardiovascular events, and number of falls and fractures among older adults. Vitamin D for health: A global perspective. [, Anglin RES, Samaan Z, Walter SD, McDonald SD. Join the ODS Email List. If you Google cforyourself vitamin d toxicity, it has answered all of my questions that all the doctor's couldn't. The blog writer is a scientist and it's very interesting to read. Vitamin D deficiency or insufficiency did not increase the risk of prostate cancer, and higher 25(OH)D concentrations were not associated with a lower risk. Arterioscler Thromb Vasc Biol 2012;32:2794-802. Circulation 2013;128:2517-31. Poor oral health. Type B UV (UVB) radiation with a wavelength of approximately 290320 nanometers penetrates uncovered skin and converts cutaneous 7-dehydrocholesterol to previtamin D3, which in turn becomes vitamin D3. The data on supplemental vitamin D and cholesterol levels are mixed, as shown in one meta-analysis of 41 clinical trials in a total of 3,434 participants (mean age 55 years). One systematic review and meta-analysis evaluated 35 clinical trials that included 43,407 adults with normal glucose tolerance, prediabetes, or type 2 diabetes who received a median of 83 mcg (3,332 IU)/day vitamin D supplements or placebo for a median of 16 weeks [148].
Studies have also assessed the value of vitamin D supplementation for managing diabetes, and they have found that the vitamin offers limited benefits.
Effects of atorvastatin on vitamin D levels in patients with acute ischemic heart disease. Screening for vitamin D deficiency: Systematic review for the U.S. Preventive Services Task Force recommendation. Jones G. Vitamin D. In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds.
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Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study.
Older adults
1000 mg is 40,000,000 (forty million) IU. [, Jorde R, Kubiak J. The VITAL trial found no association between vitamin D supplementation and the risk of colorectal adenomas or serrated polyps [103].
National Institutes of Health Osteoporosis and Related Bone Diseases National Resource Center. It also helps keep your muscles, nerves, and immune system working normally.
Vitamin C helps in maintaining a healthy immune system, it aids in neutralizing pollutants, is needed for antibody production, acts to increase the absorption of nutrients (including iron) in the gut, and thins the blood. Homebound individuals; people who wear long robes, dresses, or head coverings for religious reasons; and people with occupations that limit sun exposure are among the groups that are unlikely to obtain adequate amounts of vitamin D from sunlight [62]. [, Cauley JA, Chlebowski RT, Wactawski-Wende J, Robbins JA, Rodabough RJ, Chen Z, et al. Federal agencies and national organizations advise taking photoprotective measures to reduce the risk of skin cancer, including using sunscreen with a sun protection factor (SPF) of 15 or higher, whenever people are exposed to the sun [28,30]. [, Zhang R, Li B, Gao X, Tian R, Pan Y, Jiang Y, et al. Among the women with two or more serum 25(OH)D samples taken before diagnosis (which reduced random measurement variation), a 50 nmol/L increase in 25(OH)D was associated with a 41% reduced risk of MS, and 25(OH)D levels less than 30 nmol/L were associated with an MS risk that was twice as high as levels of 50 nmol/L or higher. Individuals with a body mass index (BMI) of 30 or more have lower serum 25(OH)D levels than individuals without obesity. Nutrients 2018, 10, 59; doi:10.3390/nu10010059. Corticosteroid medications, such as prednisone (Deltasone, Rayos, and Sterapred), are often prescribed to reduce inflammation.
U.S. Preventive Services Task Force. Pancreatic cancer
Type 2 diabetes
Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: New findings from an updated meta-analysis. Prolonged exclusive breastfeeding without vitamin D supplementation can cause rickets in infants, and, in the United States, rickets is most common among breastfed Black infants and children [47]. Calcium plus vitamin D supplementation and health outcomes five years after active intervention ended: The Women's Health Initiative. It means you need fats in your body for proper absorption of vitamin D. Since vitamin D maintains calcium and phosphorous levels in our bodies, it is an essential vitamin for good bone, muscle, and teeth health. Assessing the vitamin D status of the US population. Here are my top 8 foods rich in vitamin D to start adding into your regimen: 1. The impact of this form on vitamin D status is an emerging area of research. Nutr Metab Cardiovasc Dis 2016;26:663-73. Sempos CT, Carter GD, Binkley NC. Nutrients 2018; 10, 375; doi:10.3390/nu10030375 [, Mousa A, Naderpoor N, Teede H, Scragg R, de Courten, B. Vitamin D supplementation for improvement of chronic low-grade inflammation in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials. Factors such as adiposity, skin pigmentation, vitamin D binding protein polymorphisms, and genetics contribute to differences in 25(OH)D levels between Black and White Americans. [, Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. An animal-free version of vitamin D3 sourced from lichen is also available [32].
[, Uday S, Hogler W. Nutritional rickets and osteomalacia in the twenty-first century: Revised concepts, public health, and prevention strategies. The 'sunshine vitamin': benefits beyond bone?
Below are brief descriptions of studies of vitamin D and its association with, or effect on, breast, colorectal, lung, pancreatic, and prostate cancers. Clinical management of low vitamin D: A scoping review of physicians' practices.
The products you buy from Cforyourself are the same price as if you had bought them directly from Nutribiotic.
Hypercalcemia, in turn, can lead to nausea, vomiting, muscle weakness, neuropsychiatric disturbances, pain, loss of appetite, dehydration, polyuria, excessive thirst, and kidney stones.
[, O'Brien KM, Sandler DP, Taylor JA, Weinberg CR. Holick MF. Individuals who have difficulty absorbing dietary fat might therefore require vitamin D supplementation [63].
No studies have examined whether such screening for vitamin D deficiency results in improved health outcomes [55]. [, Beveridge LA, Struthers AD, Khan F, Jorde R, Scragg R, Macdonald HM, et al. However, because research has been conducted on vitamin D and numerous health outcomes, this section focuses on seven diseases, conditions, and interventions in which vitamin D might be involved: bone health and osteoporosis, cancer, cardiovascular disease (CVD), depression, multiple sclerosis (MS), type 2 diabetes, and weight loss.
Breast cancer
J Clin Endocrinol Metab 2013;98:4845-51. Observational studies support an association between higher serum 25(OH)D levels and a lower risk of CVD incidence and mortality. One nmol/L is equal to 0.4 ng/mL, and 1 ng/mL is equal to 2.5 nmol/L. It is found in fortified food and some supplements. Modern Nutrition in Health and Disease, 11th ed.
This U-shaped association was most pronounced for men with the most aggressive forms of prostate cancer.
In fact, Black Americans might have a greater risk than White Americans of falls and fractures with daily vitamin D intakes of 50 mcg (2,000 IU) or more [14].
In adults and adolescents, vitamin D deficiency can lead to osteomalacia, in which existing bone is incompletely or defectively mineralized during the remodeling process, resulting in weak bones [46]. Some expert bodies and vitamin D researchers suggest, for example, that approximately 530 minutes of sun exposure, particularly between 10 a.m. and 4 p.m., either daily or at least twice a week to the face, arms, hands, and legs without sunscreen usually leads to sufficient vitamin D synthesis [13,15,28].
[, Vaes AMM, Tieland M, Toussaint N, Nilwik R, Verdijk LB, van Loon LJC, de Groot CPGM. [, Rooney MR, Harnack L, Michos ED, Ogilvie RP, Sempos CT, Lutsey PL.
Am J Clin Nutr 2016;104:1151-9.
Cancer Epidemiol Biomarkers Prev 2014;23:1494-504. [, Schenk JM, Till CA, Tangen CM, Goodman PJ, Song X, Torkko KC, et al. Vitamin D, calcium, and cancer: Approaching daylight? uss canberra crew list. Paediatr Int Child Health 2017;37:84-98. The first hydroxylation, which occurs in the liver, converts vitamin D to 25-hydroxyvitamin D [25(OH)D], also known as "calcidiol." [, Simon AE, Ahrens KA.
Cancer Epidemiol Biomarkers Prev 2014;23:1484-93. U.S. Department of Agriculture, Agricultural Research Service. Yao P, Bennett D, Mafham M, Lin X, Chen Z, Armitage J, Clarke R. Vitamin D and calcium for the prevention of fracture: A systematic review and meta-analysis.
Vitamin D helps you absorb calcium and phosphate from food. The importance of 25-hydroxyvitamin D assay standardization and the Vitamin D Standardization Program. Newberry SJ, Chung M, Shekelle PG, Booth MS, Liu JL, Maher AR, et al.
Hazards of treating osteoporosis and hypertension concurrently with calcium, vitamin D, and distal diuretics. Vitamin D supplements may interact with several types of medications.
19.98.
and some exceptional products like: Butterfat Keto, Advanced Collagen and Altrient C, Neutrient put a group of #CForYourself volunteers onto the 5C Reset and achieved outstanding results. This is a fact sheet intended for health professionals. One study, for example, tested 25(OH)D levels in 1,092 women in Finland an average of 9 years before their MS diagnosis and compared their outcomes with those of 2,123 similar women who did not develop MS [139]. DOI: 10.1002/14651858.CD008422.pub3. JAMA 2017;317:1217-8. [, Schwartz JB. Best liquid: Designs for Health Liposomal D Supreme. Vitamin D. In: Erdman JW, Macdonald IA, Zeisel SH, eds.
Curr Osteoporos Rep 2017;15:293-302.
The effect of vitamin D supplementation on lower-extremity power and function in older adults: a randomized controlled trial.
Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter months. But despite the importance of the sun for vitamin D synthesis, limiting skin exposure to sunlight and UV radiation from tanning beds is prudent [28].
$12.99. The effect of vitamin D supplementation on glycemic control in type 2 diabetes patients: A systematic review and meta-analysis.
Statin medications reduce cholesterol synthesis. Cancer
Elsevier, 2018. Trends in use of high-dose vitamin D supplements exceeding 1000 or 4000 International Units daily, 1999-2014.
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